Endocrine Abstracts

Introduction: Cushing’s disease (CD) is associated with metabolic and cardiovascular comorbidities that can be incompletely resolved after disease remission. Our objective was to evaluate the metabolic and cardiovascular status of patients with MC in remissionPatients and methods: We performed a retrospective study including 15 CD patients cured by pituitary surgery. Patient’s medical records were reviewed and information regarding blood pressu...

Introduction: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders that result from the deficiency of one of several enzymes involved in the steroidogenic pathway for cortisol biosynthesis. The most common cause of CAH, accounting for 90% of cases, is 21-hydroxylase deficiency. The symptoms of disease very depending on the nature and severity of the enzyme deficiency as well as the sex of the individual. Non-classical CAH is generally late onset. Ho...

Introduction: Central diabetes insipidus (CDI) is a heterogeneous condition characterized by the presence of polyuria and polydipsia due to a deficiency of arginine vasopressin. Frequently, CDI is wrongly considered idiopathic if not associated with other signs and symptoms.Case report: We report the case of a 50-year-old woman diagnosed with idiopathic central diabetes insipidus at the age of 34. The MRI scan of the hypothalamus and pituitary gland was ...

Introduction: Acromegaly is a chronic disorder usually caused by growth hormone (GH)-secreting pituitary adenomas. Transsphenoidal surgery remains a treatment of choice for restoring GH to normal levels. The aim of this study was to illustrate the relationship between some factors and transsphenoidal surgery outcomes.Patients and methods: We retrospectively analysed the outcome of 31 patients with acromegaly after initial endoscopic transsphenoidal surge...

Introduction: Leydig cell tumors (LCTs) are uncommon neoplasms arising from gonadal stroma, accounting for 1–3% of all testicular tumors in adults. The etiology of LCT remains unclear. About 25% of LCTs secrete predominantly estrogens, which produce gynecomastia.Observation: We report a case of a 53-year-old male patient who sought evaluation for bilateral gynecomastia. He had a long-term use of amitriptyline and benzodiazepine. The physical examin...

Introduction: Medullary thyroid carcinoma (MTC) represents 3–10% of all thyroid cancer. The presence of papillary thyroid microcarcinoma (mPTC) in patients undergoing thyroidectomy for multinodular goiter has been reported as 3–7%.The occurrence of multiple thyroid cancers of different origin in one individual patient is a rare event. We report the case of synchronous papillary and medullary thyroid cancer developed in heterogynous recurrent ...

Introduction: In order to avoid the spread of the Corona Virus disease, Tunisia has imposed strict confinement measures. The lockdown may change Tunisian’s physical activities.The aim of this study was to evaluate the impact of COVID-19 lockdown on physical activity among adults in Tunisia.Methods: It was a transversal study conducted from 31th of May to 06th of June 2020. The target audience was adults aged between 18 and 65...

Introduction: Schmidt’s syndrome also known as autoimmune polyglandular syndrome type 2 (APS type 2) is a rare endocrine disorder defined by the combined occurrence of Addison disease with autoimmune thyroid disease. The rarity of the condition and the atypical presentation of adrenal insufficiency and hypothyroidism often lead to misdiagnosis with life-threatening consequences for the patient. In this study we report an exhaustive monocentric analysis of 22 patients diag...

Aim: The aim of our study was to describe the lipid profile of Tunisian women after pregnancy with gestational diabetes mellitus (GDM) and to analyze the influence of maternal age, insulin requirement and postpartum glycemic status on lipoproteins changes after pregnancy.Methods: We conducted a cross-sectional study among pregnant women who were referred to the national institute of nutrition for management of GDM. The lipid profile included total choles...

Introduction: The insulin tolerance test (ITT) is accepted as the gold-standard test in the evaluation of adrenal and GH axis in patients with pituitary disorders. Diagnostic criteria that requires a minimum increment in serum cortisol is considered invalid although individuals who have a lower basal serum cortisol concentration because of recent ACTH deficiency may be maximally stimulated by ITT and thus able to further increase cortisol secretion without reaching the cut-off...